La hormona tiroidea suprime la progresión del meduloblastoma mediante la promoción de la diferenciación terminal de las células tumorales
Sólo se conocen unos pocos compuestos que hacen esto.
La tiroides es ahora uno de ellos. [eng]
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etiquetas: cancer , ciencia , tiroides 
Igualmente te copio y pego
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T3 induces terminal differentiation of MB tumor cells through upregulating NeuroD1
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T3 promotes NeuroD1 transcription by interfering with TRα1 and EZH2 interaction
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T3 represses the growth of human and mouse tumors from multiple MB groups
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T3-induced differentiation is an effective and safe strategy for MB treatment
Summary
Hypothyroidism is commonly detected in patients with medulloblastoma (MB). However, whether thyroid hormone (TH) contributes to MB pathogenicity remains undetermined. Here, we find that TH plays a critical role in promoting tumor cell differentiation. Reduction in TH levels frees the TH receptor, TRα1, to bind to EZH2 and repress expression of NeuroD1, a transcription factor that drives tumor cell differentiation. Increased TH reverses EZH2-mediated repression of NeuroD1 by abrogating the binding of EZH2 and TRα1, thereby stimulating tumor cell differentiation and reducing MB growth. Importantly, TH-induced differentiation of tumor cells is not restricted by the molecular subgroup of MB, suggesting that TH can be used to broadly treat MB subgroups. These findings establish an unprecedented association between TH signaling and MB pathogenicity, providing solid evidence for TH as a promising modality for MB treatment.
Graphical abstract
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Keywords
medulloblastoma
differentiation therapy
terminal differentiation
thyroid hormone
hypothyroidism
epigenetic regulation
EZH2
NeuroD1
TRα1
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Mi pantallazo, vaya
"Thyroid hormone suppresses medulloblastoma progression through promoting terminal differentiation of tumor cells" Título original.
O sea, la hormona tifoidea frena/revierte 1 tipo de cáncer.
Lo siento, pero microblogging, has cambiado por completo el sentido
Pero sigue siendo interesante, como he dicho.